Title Page Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity
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Critical role for mixed-lineage kinase 3 in acetaminophen-induced hepatotoxicity.
c-Jun NH(2)-terminal kinase (JNK) activation plays a major role in acetaminophen (APAP)-induced hepatotoxicity. However, the exact mechanism of APAP-induced JNK activation is incompletely understood. It has been established that apoptosis signal-regulating kinase 1 (ASK1) regulates the late phase of APAP-induced JNK activation, but the mitogen-activated protein kinase kinase kinase that mediate...
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